Post-cricoid Carcinoma in Patients with Pernicious Anaemia

Post-cricoid carcinoma in patients with pernicious anaemia.

Post-cricoid carcinoma occurs mainly in women and is often associated with a history of iron-deficiency anaemia. In some cases dysphagia has been present for many years. An association of this type of cancer with pernicious anaemia is not generally recognized. A recent study of 93 cases of post-cricoid carcinoma (Jacobs, 1961a) showed that 29 had suffered from iron-deficiency anaemia and that f...

Surgical treatment of post-cricoid carcinoma.

Pernicious anaemia.

DEFICIENCY of vitamin B12 (cyanocobalamin) in man results in a macrocytic animia, leucopa2nia, the appearance of megaloblasts and giant band cells in the marrow, reduced formation of platelets, and also-changes in the peripheral and central nervous systems. In temperate climates the most common cause of vitamin B12 deficiency is pernicious anaemia. This is by no means a rare disease, having an ...

Pernicious Anaemia with Gastric Carcinoids.

We report the case of a 42 year male with history of chronic anaemia who was found to have pernicious anaemia with beta thalassemia trait and had on esophago-gastric-duodenoscopy, gastric carcinoids with gastric atrophy. Pernicious anaemia and gastric carcinoids occurring simultaneously in a single individual is rare. Our case emphasises the need for esophago-gastric-duodenoscopy in cases of pe...

Gastroscopic screening in 80 patients with pernicious anaemia.

We have studied 80 patients with pernicious anaemia. Upper gastrointestinal endoscopy (with biopsy and cytology) showed no lesion other than atrophic gastritis in 34 patients. Thirty three patients, however, had varying degrees of gastric mucosal dysplasia, which was detected more frequently by histology than by cytology. The endoscopic appearance of the mucosa was abnormal in four of the six p...